Accidental overdosage could occur during therapy, particularly in patients with renal impairment. Treatment of overdosage should be symptomatic and supportive. There is no known antidote. In the event of overdosage, meropenem should be discontinued and general supportive treatment given until renal elimination takes place. In normal individuals, rapid renal elimination will occur; in subjects with renal impairment, hemodialysis will remove meropenem and its metabolite.
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